Low-Temperature Thermodynamic Properties of Nucleosides: Uridine and Deoxyuridine

Precision data on the heat capacity in the range 6–330 K of crystalline synthetic samples of nucleosides, uridine (C9H12N2O6; CAS Number: 58–96–8; fraction purity: 0.999), and deoxyuridine (C9H12N2O5; CAS Number: 951–78–0; fraction purity: 0.999), are provided herein. This was the first time that the heat capacity of the substances was measured by vacuum adiabatic calorimetry. The heat capacity was found to have no anomalies indicating phase transitions in the tested temperature range. The heat capacity experimental data were used to calculate the entropy, enthalpy, and reduced Gibbs energy for uridine and deoxyuridine in the range 0–330 K. The obtained results are important for understanding the energetics of biochemical processes involving nucleosides, assessing their pharmacological properties and expanding the possibilities of their application.