Transcriptional deregulation by FOXM1–JUP signaling confers dual oncogenic drivers for pancreatic tumorigenesis and therapeutic resistance
Therefore, our findings suggest that JUP promotes PDAC tumorigenesis and progression through FOXM1-JUP transcriptional axis and the combination of FOXM1 and JUP be a more precise biomarker for targeted therapy and prognostic prediction, nominating this dyad as an actionable vulnerability for molecularly targeted interventions in PDAC.
Authors
- Keping Xie (ORCID: https://orcid.org/0000-0001-7887-9586)
- Xiaojia Li (ORCID: https://orcid.org/0000-0002-7833-3775)
- Tian Cai
- Zhihong He
- Tingting Jiang (ORCID: https://orcid.org/0000-0002-5372-0656)
- Kailing Yang
Institutions
- First People's Hospital of Foshan (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s12964-025-02512-5
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China