Identification of Gαi1 as a key regulator of tumor progression in nasopharyngeal carcinoma
Gαi1 promotes tumor progression in NPC through the cell cycle, ERK and Akt-mTOR pathway and by regulating SETD7. Targeting Gαi1 or its signaling may offer a novel therapeutic strategy for NPC and potentially other cancers.
Authors
- Ting Chen (ORCID: https://orcid.org/0000-0003-0179-3586)
- Huijun Yang (ORCID: https://orcid.org/0000-0003-1121-7806)
- Ling Ji (ORCID: https://orcid.org/0000-0003-4814-9085)
- Yeqin Sha (ORCID: https://orcid.org/0000-0002-7726-1749)
- Yan Lv (ORCID: https://orcid.org/0000-0002-8344-1690)
- Donghui Li
Institutions
- Soochow University (CN)
- Zhangjiagang First People's Hospital (CN)
- Second Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1007/s12672-025-04157-9
- Primary Topic
- Protein Kinase Regulation and GTPase Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00