Senescent bone marrow mesenchymal stem cells exacerbate subchondral bone sclerosis and osteoarthritis via the senescence-associated secretory phenotype
This study indicates that senescent BMSCs promote subchondral bone sclerosis and OA progression through activating Mapk8 and Mapk14 via SASP in subchondral bone. The senolytic combination D + Q holds potential for OA treatment by eliminating senescent BMSCs in subchondral bone.
Authors
- Yuheng Yan
- Xin Xu (ORCID: https://orcid.org/0000-0002-2469-6933)
- Yirixiati Aihaiti
- Erliang Li
- Chao Lu (ORCID: https://orcid.org/0000-0002-7705-1098)
- Mingyi Yang (ORCID: https://orcid.org/0000-0001-8640-9795)
- Ke Xu (ORCID: https://orcid.org/0000-0003-4364-3770)
- Peng Xu (ORCID: https://orcid.org/0000-0003-2487-9163)
- Dinglong Yang (ORCID: https://orcid.org/0000-0002-9288-5832)
- Yangquan Hao (ORCID: https://orcid.org/0000-0002-3424-8691)
Institutions
- Xi'an Honghui Hospital (CN)
- Xi'an Institute of Optics and Precision Mechanics (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s13287-025-04833-1
- Citations
- 1
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 1.16