Acid Vapor Responsive Coumarin Coupled Imidazole as Colorimetric and Fluorometric Co <sup>2+</sup> Sensor, DFT, and Zebrafish Bioimaging Studies

This work describes a novel Co<sup>2+</sup> ion sensor 3-(2-(2-(4-nitrophenyl)-4,5-diphenyl-1H-imidazol-1-yl)thiazol-4-yl)-2H-chromen-2-one (NBIC) comprising imidazole and a coumarin-thiazole moiety. When Co<sup>2+</sup> is present, NBIC shows a notable quenching of fluorescence at 450 nm as a result of complex formation. The limit of detection was found to be 7 μM under optimal conditions. It was discovered that the sensor was quite selective for Co<sup>2+</sup> ions despite many competing ions. The chemosensor NBIC also exhibited colorimetric and fluorometric sensing ability with a visible colorimetric response to trifluoroacetic acid (TFA). The Job's plot validates the 1:1 binding stoichiometry between Co<sup>2+</sup> and NBIC. Further, the study was also validated with zebrafish bioimaging studies.

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Publication Details

Journal
Luminescence
Published
2025-11-27
DOI
https://doi.org/10.1002/bio.70368
Primary Topic
Molecular Sensors and Ion Detection
Type
article
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article

Acid Vapor Responsive Coumarin Coupled Imidazole as Colorimetric and Fluorometric Co 2+ Sensor, DFT, and Zebrafish Bioimaging Studies

Nirnay Bansal, K. D. Venuprasad, Nabil Al‐Zaqri, Sharanappa Chapi et al.
Luminescence
Molecular Sensors and Ion Detection
article

Acid Vapor Responsive Coumarin Coupled Imidazole as Colorimetric and Fluorometric Co 2+ Sensor, DFT, and Zebrafish Bioimaging Studies

Nirnay Bansal, K. D. Venuprasad, Nabil Al‐Zaqri, Sharanappa Chapi, Aravind R. Nesaragi, Sanjeev R. Inamdar, Naveen Kumar Kalagatur, Thakur Gurjeet Singh, H. P. Shivarudrappa, Jyoti Nagalik
article en

Abstract

This work describes a novel Co<sup>2+</sup> ion sensor 3-(2-(2-(4-nitrophenyl)-4,5-diphenyl-1H-imidazol-1-yl)thiazol-4-yl)-2H-chromen-2-one (NBIC) comprising imidazole and a coumarin-thiazole moiety. When Co<sup>2+</sup> is present, NBIC shows a notable quenching of fluorescence at 450 nm as a result of complex formation. The limit of detection was found to be 7 μM under optimal conditions. It was discovered that the sensor was quite selective for Co<sup>2+</sup> ions despite many competing ions. The chemosensor NBIC also exhibited colorimetric and fluorometric sensing ability with a visible colorimetric response to trifluoroacetic acid (TFA). The Job's plot validates the 1:1 binding stoichiometry between Co<sup>2+</sup> and NBIC. Further, the study was also validated with zebrafish bioimaging studies.

LuminescenceVol. 40(12)
Karnatak University (IN), JSS Academy of Higher Education and Research (IN), Acharya Nagarjuna University (IN), International Institute of Information Technology Bangalore (IN), University of Mysore (IN), Dongguk University (KR), King Saud University (SA), Graphic Era University (IN), Chitkara University (IN)
Openalex Percentile: Top 66%
Molecular Sensors and Ion Detection
DOISourceOpenAlex
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Acid Vapor Responsive Coumarin Coupled Imidazole as Colorimetric and Fluorometric Co <sup>2+</sup> Sensor, DFT, and Zebrafish Bioimaging Studies — Nirnay Bansal, K. D. Venuprasad, et al. · Luminescence (2025) | TGRS Research Map | TGRS