Oxidative Amidation of Aldehydes With Amine Hydrochloride Salts in Deep Eutectic Solvents: The Dual Role of Urea: CuCl ₂ .2H ₂ O Acting as Both Catalyst and Solvent

ABSTRACT The direct coupling of aldehydes and amines, known as oxidative amidation, toward synthesis of amides, is reported for the first time in Urea:CuCl 2 .2H 2 O deep eutectic solvent, which simultaneously also plays the role of a catalyst. tert ‐Butyl hydroperoxide (TBHP) was employed as a green oxidant, and all the reactions were performed at 80°C. More than 20 amide derivatives were synthesized in good to excellent yields. Urea.2H 2 O was employed as both a solvent and a catalyst for the synthesis of 22 amides with yields of up to 95% via oxidative amidation reactions of aldehydes and amine hydrochloride salts.