Construction of Carbon‐Nitrogen Bond From Addition Reaction of Weak Nucleophilic Nitrogen Atom of Imides With <i>Para</i> ‐Quinone Methides
ABSTRACT An efficient 1,6‐conjugate addition for the construction of C–N bonds from the reaction of para ‐Quinone methides ( p ‐QMs) and the weak nucleophilic nitrogen atom of imides was reported. Studies have shown that trimethylamine (Et 3 N) is an essential catalyst for ensuring the successful completion of this synthesis process. The reaction features a wide range of substrates, simple operation, good group tolerance, and high yields.
Authors
- Liangce Rong (ORCID: https://orcid.org/0000-0003-0561-1137)
- Yi‐Ting Wang (ORCID: https://orcid.org/0000-0003-2008-4435)
- Feixiang Luo
- G. L. TONG
Institutions
- Jiangsu Normal University (CN)
- Xuzhou Medical College (CN)
- Jiangsu Nhwa Pharmaceutical (China) (CN)
- Second Affiliated Hospital of Xuzhou Medical College (CN)
Publication Details
- Journal
- Journal of Heterocyclic Chemistry
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1002/jhet.70141
- Primary Topic
- Synthesis of Indole Derivatives
- Type
- article
- Field-Weighted Citation Impact
- 0.00