Physical activity and diurnal variation have no impact on plasma microRNA-140 expression levels in patients with knee osteoarthritis and healthy controls
Plasma miR-140-3p and miR-140-5p expression levels were found in all samples; however, the expression levels were not affected by physical activity and did not show diurnal variation. The observation of stable miR-140 expression supports its potential as a reliable biomarker for OA, providing a methodological foundation for future diagnostic and translational studies.
Authors
- Rune Bruhn Jakobsen (ORCID: https://orcid.org/0000-0003-3566-9516)
- Per‐Henrik Randsborg (ORCID: https://orcid.org/0000-0002-7674-1572)
- Tommy Frøseth Aae (ORCID: https://orcid.org/0000-0003-3643-0822)
- Mai Britt Dahl (ORCID: https://orcid.org/0009-0002-6085-5337)
- Asbjørn Årøen (ORCID: https://orcid.org/0000-0002-2337-0755)
- Øystein Bjerkestrand Lian
- Mingma Hoel (ORCID: https://orcid.org/0009-0008-9615-2741)
Institutions
- University of Oslo (NO)
- Norwegian University of Science and Technology (NO)
- Akershus University Hospital (NO)
- Oslo Sports Trauma Research Center (NO)
- Kristiansund Sykehus (NO)
- Helse Møre og Romsdal HF (NO)
- Norwegian School of Sport Sciences (NO)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1016/j.ocarto.2025.100720
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00