ShapeField-lung: continuous shape embedding for early lung cancer detection via pulmonary nodule segmentation

Accurate segmentation of pulmonary nodules in low-dose CT (LDCT) is vital for early lung cancer detection. Existing voxel-based methods often fail to capture irregular nodule boundaries, especially under noisy, low-contrast conditions. We propose ShapeField-Nodule, a continuous shape embedding framework that models nodule geometry as a signed distance field (SDF), enabling sub-voxel precision and anatomically coherent contours. Our method integrates a lightweight MLP-based implicit head with a 3D U-Net backbone to predict dense SDF values, and introduces a shape-aware refinement loss that aligns SDF gradients with image edges. Unlike discrete masks, our representation enforces boundary smoothness, topology regularization, and robustness to perturbations. Evaluations on LIDC-IDRI, LUNA16, and Tianchi datasets show state-of-the-art Dice and surface metrics. Extensive experiments demonstrate superior generalization, robustness under noise, and inference efficiency, highlighting the potential of continuous implicit fields as a principled alternative for medical image segmentation.

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Publication Details

Journal
npj Digital Medicine
Published
2025-11-27
DOI
https://doi.org/10.1038/s41746-025-02041-y
Primary Topic
Lung Cancer Diagnosis and Treatment
Type
article
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article

ShapeField-lung: continuous shape embedding for early lung cancer detection via pulmonary nodule segmentation

Xuyu Gu, Chuangqi Li, Xinnan Xu, Li Xu et al.
npj Digital Medicine
Lung Cancer Diagnosis and Treatment
article

ShapeField-lung: continuous shape embedding for early lung cancer detection via pulmonary nodule segmentation

Xuyu Gu, Chuangqi Li, Xinnan Xu, Li Xu, Yifei Zhu, Kaiqi Jin
article en

Abstract

Accurate segmentation of pulmonary nodules in low-dose CT (LDCT) is vital for early lung cancer detection. Existing voxel-based methods often fail to capture irregular nodule boundaries, especially under noisy, low-contrast conditions. We propose ShapeField-Nodule, a continuous shape embedding framework that models nodule geometry as a signed distance field (SDF), enabling sub-voxel precision and anatomically coherent contours. Our method integrates a lightweight MLP-based implicit head with a 3D U-Net backbone to predict dense SDF values, and introduces a shape-aware refinement loss that aligns SDF gradients with image edges. Unlike discrete masks, our representation enforces boundary smoothness, topology regularization, and robustness to perturbations. Evaluations on LIDC-IDRI, LUNA16, and Tianchi datasets show state-of-the-art Dice and surface metrics. Extensive experiments demonstrate superior generalization, robustness under noise, and inference efficiency, highlighting the potential of continuous implicit fields as a principled alternative for medical image segmentation.

npj Digital MedicineVol. 8(1)
Shanghai Medical College of Fudan University (CN), Fudan University Shanghai Cancer Center (CN), Shanghai Pulmonary Hospital (CN), Tsinghua University (CN)
Openalex Percentile: Top 45%
Lung Cancer Diagnosis and Treatment
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