ShapeField-lung: continuous shape embedding for early lung cancer detection via pulmonary nodule segmentation
Accurate segmentation of pulmonary nodules in low-dose CT (LDCT) is vital for early lung cancer detection. Existing voxel-based methods often fail to capture irregular nodule boundaries, especially under noisy, low-contrast conditions. We propose ShapeField-Nodule, a continuous shape embedding framework that models nodule geometry as a signed distance field (SDF), enabling sub-voxel precision and anatomically coherent contours. Our method integrates a lightweight MLP-based implicit head with a 3D U-Net backbone to predict dense SDF values, and introduces a shape-aware refinement loss that aligns SDF gradients with image edges. Unlike discrete masks, our representation enforces boundary smoothness, topology regularization, and robustness to perturbations. Evaluations on LIDC-IDRI, LUNA16, and Tianchi datasets show state-of-the-art Dice and surface metrics. Extensive experiments demonstrate superior generalization, robustness under noise, and inference efficiency, highlighting the potential of continuous implicit fields as a principled alternative for medical image segmentation.
Authors
- Xuyu Gu (ORCID: https://orcid.org/0000-0001-7739-5301)
- Chuangqi Li
- Xinnan Xu (ORCID: https://orcid.org/0000-0002-5508-6716)
- Li Xu (ORCID: https://orcid.org/0000-0001-5968-5751)
- Yifei Zhu (ORCID: https://orcid.org/0000-0001-5393-0445)
- Kaiqi Jin
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Pulmonary Hospital (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- npj Digital Medicine
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1038/s41746-025-02041-y
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00