Insulin resistance in patients with schizophrenia: is it related to gut permeability?
We aimed to examine the association between gut permeability biomarkers (LBP, sCD14) and insulin resistance (IR) in schizophrenia. In this cross-sectional study of 91 patients, IR (HOMA-IR ≥ 3.0) was associated with higher LBP, C-reactive protein, body mass index (BMI), and lower physical activity. Logistic regression identified LBP and BMI as independent risk factors, whereas physical activity was protective. These findings suggest altered gut permeability could influence glucose metabolism dysfunction in schizophrenia.
Authors
- G. Paniagua
- Manuel Couce-Sánchez (ORCID: https://orcid.org/0000-0002-2183-3824)
- María Paz García‐Portilla (ORCID: https://orcid.org/0000-0003-3643-1622)
- Pilar A. Sáiz (ORCID: https://orcid.org/0000-0002-5705-4523)
- Francesco Dal Santo (ORCID: https://orcid.org/0000-0002-9879-6443)
- Leticia González-Blanco
- Julia Rodríguez-Revuelta
Institutions
- Universidad de Oviedo (ES)
- Gobierno del Principado de Asturias (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Instituto de Investigación Sanitaria del Principado de Asturias (ES)
Publication Details
- Journal
- Schizophrenia
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1038/s41537-025-00688-w
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gobierno del Principado de Asturias
- European Commission
- Ministerio de Economía y Competitividad
- Instituto de Salud Carlos III