Arsenicum iodatum and arseicum album induces apoptosis and autophagy in glioblastoma multiforme

Glioblastoma multiforme (GBM) is a highly aggressive and treatment-resistant brain tumor, highlighting the need for novel therapeutic strategies. Therefore, it is of interest to investigate the anti-cancer effects of Arsenicum iodatum and Arsenicum album in U87 glioblastoma cells at 6C, 12C and 30C potencies. Both preparations induced apoptosis, confirmed by TUNEL along with the caspase-3 assays and triggered autophagy, evidenced by reduced p62 levels. Inhibition of autophagy enhanced cytotoxicity, indicating its protective role in GBM cells. Thus, we show that Arsenicum iodatum and Arsenicum album may serve as complementary candidates for GBM therapy, warranting further <i>in vivo</i> and mechanistic studies.