When Numbers Lie: A Case Report of Falsely Low Hemoglobin Due to Preanalytical Error Leading to Unnecessary Interventions

False laboratory values can trigger extensive and unnecessary diagnostic and therapeutic workups. We report a case of falsely diagnosed severe anemia that led to blood transfusions and a comprehensive evaluation, which included aggressive intervention as an endoscopy, before being traced back to a preanalytical sample collection error. Proper phlebotomy technique and education, clinical correlation, and sometimes confirmatory labs can help avoid scenarios like the one presented in this case report.

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Journal
Cureus
Published
2025-11-27
DOI
https://doi.org/10.7759/cureus.97937
Primary Topic
Clinical Laboratory Practices and Quality Control
Type
article
Field-Weighted Citation Impact
0.00
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article

When Numbers Lie: A Case Report of Falsely Low Hemoglobin Due to Preanalytical Error Leading to Unnecessary Interventions

Adam Zoubi
Cureus
Clinical Laboratory Practices and Quality Control
article

When Numbers Lie: A Case Report of Falsely Low Hemoglobin Due to Preanalytical Error Leading to Unnecessary Interventions

Adam Zoubi
article en

Abstract

False laboratory values can trigger extensive and unnecessary diagnostic and therapeutic workups. We report a case of falsely diagnosed severe anemia that led to blood transfusions and a comprehensive evaluation, which included aggressive intervention as an endoscopy, before being traced back to a preanalytical sample collection error. Proper phlebotomy technique and education, clinical correlation, and sometimes confirmatory labs can help avoid scenarios like the one presented in this case report.

CureusVol. 17(11)
CHRISTUS Spohn Hospital Corpus Christi - Memorial (US)
Openalex Percentile: Top 54%
Clinical Laboratory Practices and Quality Control
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