An epigenome-wide analysis of DNA methylation, racialized and economic inequities, and air pollution
Overall, this work suggests that DNAm is a biological mechanism through which structural racism and air pollution (of which distribution of exposure is inequitable) become embodied and may lead to health inequities. Due to the extensive range of exposures we tested, further replication in additional studies and other tissues is warranted.
Authors
- Christian Testa (ORCID: https://orcid.org/0000-0001-9103-5839)
- Kate M. Tilling (ORCID: https://orcid.org/0000-0002-1010-8926)
- Andrew J. Simpkin (ORCID: https://orcid.org/0000-0002-4975-444X)
- Matthew Suderman (ORCID: https://orcid.org/0000-0002-2715-9930)
- Brent A. Coull (ORCID: https://orcid.org/0000-0002-1808-4156)
- Immaculata De Vivo (ORCID: https://orcid.org/0000-0002-7185-7402)
- Jarvis T. Chen (ORCID: https://orcid.org/0000-0002-7412-1783)
- Pamela D. Waterman (ORCID: https://orcid.org/0000-0003-0187-7165)
- Sarah Watkins (ORCID: https://orcid.org/0000-0002-8034-8095)
- Nancy Krieger (ORCID: https://orcid.org/0000-0002-4815-5947)
- Caroline Relton (ORCID: https://orcid.org/0000-0001-7272-5308)
- George Davey Smith
- Ana V. Diez-Roux
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Ollscoil na Gaillimhe – University of Galway (IE)
- University of Bristol (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Drexel University (US)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s13148-025-01929-6
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00