High-fat diet-induced anorexia in rats: involving orosensory deficits, gastrointestinal dysfunction, intestinal taste receptor downregulation and dopamine signaling dysregulation
HFD consumption effectively induced anorexia in young rats, which was accompanied by gastrointestinal dysfunction, a reduction in taste buds, impaired gut-brain axis taste transduction and a suppressed central DA response. These results indicate that peripheral-central axis impairment may be an important pathological phenomenon in HFD-induced anorexia.
Authors
- Zequn Liu
- Qina Ye (ORCID: https://orcid.org/0000-0001-5739-9364)
- Jing Zhang (ORCID: https://orcid.org/0000-0001-9622-9560)
- Xiangna Yang (ORCID: https://orcid.org/0009-0006-5581-0811)
- Linjuan Zeng
- Zhuoming Lu
- Jian Xin Deng
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Jinan University (CN)
- Guangzhou Women and Children Medical Center (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s40001-025-03566-4
- Primary Topic
- Biochemical Analysis and Sensing Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00