Neutrophil extracellular traps and peptidylarginine deiminase 4–mediated inflammasome activation link diabetes to cardiorenal injury and heart failure
Diabetes promotes neutrophil inflammasome activation and NETosis, driving cardiac and renal inflammation and fibrosis. Peptidylarginine deiminase 4 deficiency prevents heart failure and preserves kidney function in experimental diabetes.
Authors
- Harald F. Langer (ORCID: https://orcid.org/0000-0003-2224-0518)
- Nicolas Schommer (ORCID: https://orcid.org/0000-0001-9568-9426)
- Krystin Krauel (ORCID: https://orcid.org/0000-0002-2030-1332)
- Denisa D. Wagner (ORCID: https://orcid.org/0000-0002-4494-413X)
- Lukas Andreas Heger (ORCID: https://orcid.org/0000-0002-9419-5675)
- William Chan (ORCID: https://orcid.org/0000-0001-9684-888X)
- Karin Klingel (ORCID: https://orcid.org/0000-0003-0203-2498)
- Stijn Van Bruggen (ORCID: https://orcid.org/0000-0002-5572-2196)
- Nicolas Gendron (ORCID: https://orcid.org/0000-0003-4852-4738)
- Dirk Westermann (ORCID: https://orcid.org/0000-0002-7542-1956)
- Alexander Maier (ORCID: https://orcid.org/0000-0003-0200-7495)
- Daniel Duerschmied (ORCID: https://orcid.org/0000-0001-5249-4012)
- Pierre‐André Jarrot (ORCID: https://orcid.org/0000-0002-6469-9047)
Institutions
- Boston Children's Hospital (US)
- Helmholtz Association of German Research Centres (DE)
- Harvard University (US)
- University of Freiburg (DE)
- University of Mannheim (DE)
- Heidelberg University (DE)
- University Medical Center Freiburg (DE)
- University Hospital Heidelberg (DE)
- Hôpital de la Conception (FR)
- German Centre for Cardiovascular Research (DE)
- Universitäts-Herzzentrum Freiburg-Bad Krozingen (DE)
- University Medical Centre Mannheim (DE)
- KU Leuven (BE)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1093/eurheartj/ehaf963
- Citations
- 3
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.39