Osteocytic FSH inhibition rescues bone mass and boosts fracture healing in ovariectomized mice
We identify osteocytes as direct FSH target cells. Osteocyte Fshr deletion promotes bone turnover and accelerates fracture repair in ovariectomized mice by enhancing PI3K/Akt signaling. These findings reveal a new pathophysiological mechanism for postmenopausal osteoporosis and suggest a promising therapeutic strategy targeting FSHR.
Authors
- Dong Wang (ORCID: https://orcid.org/0000-0002-2149-7146)
- Mingxin Sun
- Li-Ben Cheng
- Chao Li (ORCID: https://orcid.org/0000-0001-5723-1414)
- Xiaoli Li (ORCID: https://orcid.org/0000-0002-0762-6562)
- Juan Li (ORCID: https://orcid.org/0000-0003-0170-0466)
- Bin Chen (ORCID: https://orcid.org/0000-0002-3761-0465)
- Yonghong Zhang (ORCID: https://orcid.org/0000-0001-6188-3490)
- Yan Li (ORCID: https://orcid.org/0000-0003-0096-0813)
- Hongjie Zhou (ORCID: https://orcid.org/0000-0003-1523-7812)
- Chaoqi Wang
- Zemin Liu (ORCID: https://orcid.org/0000-0002-2261-2812)
Institutions
- Shanxi Medical University (CN)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1016/j.lfs.2025.124121
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00