Reactive oxygen species elevations in human immune cell subsets during sepsis are mitigated by norepinephrine and N-acetylcysteine
ROS levels are elevated in specific PBMC subsets in sepsis, particularly CD3+ T cells and CD14+ monocytes. NE and NAC reduced ROS accumulation <i>in vitro</i>, supporting their potential role as redox modulators. These findings warrant further mechanistic investigation into immune redox regulation in sepsis.
Authors
- Drashya Sharma (ORCID: https://orcid.org/0000-0003-0309-7779)
- David J. Farrar (ORCID: https://orcid.org/0000-0001-8584-7080)
- Seth Kirby
- Joby Thoppil (ORCID: https://orcid.org/0000-0002-3722-3369)
- Angela B Mobley
- D. Mark Courtney (ORCID: https://orcid.org/0000-0002-0905-465X)
Institutions
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- World Journal of Critical Care Medicine
- Published
- 2025-11-28
- DOI
- https://doi.org/10.5492/wjccm.v14.i4.108638
- Citations
- 1
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.80