Myocardial energy metabolism in heart failure: Systematic review and meta-analysis of Phosphorus-31 magnetic resonance spectroscopy phosphocreatine/adenosine triphosphate ratio
These findings support a clinically sizable but heterogeneous association between impaired myocardial energy metabolism-measured by reduced PCr/ATP ratio using ³¹P MRS-and heart failure. The consistency across subgroups, including HFpEF, suggests potential utility in early-stage or diagnostically challenging heart failure. The results support inclusion of PCr/ATP in prospective studies aimed at validating its clinical utility and advancing metabolic imaging toward routine cardiovascular care.
Authors
- Yang Wu (ORCID: https://orcid.org/0000-0002-0906-9667)
- Bo Jiang (ORCID: https://orcid.org/0000-0001-9446-8875)
- Nan Li (ORCID: https://orcid.org/0000-0002-7529-0781)
- Jiazheng Wang (ORCID: https://orcid.org/0000-0003-1182-442X)
- Peng Sun (ORCID: https://orcid.org/0000-0002-1931-3694)
- Jing Peng (ORCID: https://orcid.org/0000-0002-5232-6227)
- Minyue Pei
- Jianxiu Lian
Institutions
- Philips (Finland) (FI)
- Peking University (CN)
- Wuhan University (CN)
- Philips (China) (CN)
- Wuhan Asia Heart Hospital (CN)
- Peking University Third Hospital (CN)
- Wuhan General Hospital of Guangzhou (CN)
Publication Details
- Journal
- Journal of Cardiovascular Magnetic Resonance
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1016/j.jocmr.2025.101993
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00