Multi-target mechanisms of Bojungikki-tang in psoriasis-like dermatitis: Integrative network and transcriptomic analysis
This study demonstrated that BJT ameliorated psoriasis-like inflammation by concurrently regulating pivotal pro-inflammatory cytokines and two distinct steps of the AA pathway, which may be related to its multi-component composition. These findings indicate the therapeutic potential of the multi-component drug BJT on multiple targets for psoriasis-like inflammation.
Authors
- Bu‐Yeo Kim (ORCID: https://orcid.org/0000-0001-5949-2407)
- Youn‐Hwan Hwang (ORCID: https://orcid.org/0000-0002-4959-2436)
- Yu Jin Kim (ORCID: https://orcid.org/0000-0001-5152-9439)
- Seol Jang (ORCID: https://orcid.org/0000-0002-4342-0414)
- Hye Jin Kim
- Yun Hee Kim (ORCID: https://orcid.org/0000-0002-3138-3417)
- Tae Soo Kim (ORCID: https://orcid.org/0000-0002-0471-9536)
- Hyun‐Kyung Song (ORCID: https://orcid.org/0000-0002-9472-0724)
Institutions
- Mokpo National University (KR)
- Korea Institute of Oriental Medicine (KR)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1016/j.phymed.2025.157619
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00