A novel brain-derived peptide inhibits microglial pyroptosis through MBTPS1 in neonatal hypoxic-ischemic brain damage
HIBDAP inhibits microglial pyroptosis by combining with MBTPS1 to inhibit the expression of the NLRP-3/ASC/Caspase-1/GSDMD N-terminus, IL-1β and IL-18 and significantly improves motor, learning and memory-related abilities in neonatal HIBD rats.
Authors
- Yimin Dai (ORCID: https://orcid.org/0000-0002-5266-1797)
- Hong Miao (ORCID: https://orcid.org/0000-0003-4590-6781)
- Jie Qiu
- Zengqiang Yuan (ORCID: https://orcid.org/0000-0001-5739-2867)
- Shuai Lü (ORCID: https://orcid.org/0000-0002-0169-349X)
Institutions
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111664
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00