Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway
Our findings show that circNLRP12 promotes hPASMCs proliferation and dysfunction through a miR-107-5p/ITGA2 axis. As a novel biomarker and therapeutic target, it may serve as significant potential for guiding clinical interventions.
Authors
- Shaoqing Lei (ORCID: https://orcid.org/0000-0002-0093-3068)
- Zongbin Li (ORCID: https://orcid.org/0000-0003-2901-6156)
- Miao Zhao (ORCID: https://orcid.org/0009-0003-3607-5215)
- Shanshan Ma
Institutions
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s40001-025-03586-0
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00