Perspective on postoperative hormone replacement therapy and fertility preservation in Swyer syndrome with dysgerminoma: a case series and literature review

Long-term postoperative HRT (6 and 10 years) in adolescents with Swyer syndrome and dysgerminoma (following curative surgery + chemotherapy) is safe, facilitates near-normal uterine development, and supports potential fertility without recurrence. Fertility-sparing surgery is feasible, and individualized HRT dosing is warranted. The systematic review further confirms high pregnancy-related complications but favourable neonatal outcomes in patients with Swyer syndrome. Vigilant long-term surveillance and large-scale prospective studies are needed to validate long-term safety.