Whole lung directed anti-muscarinic therapy improves small airway dysfunction in COPD patients

<title>Extract</title> Small airways disease is a key feature of chronic obstructive pulmonary disease (COPD) that often precedes emphysema and is the major site of airflow limitation [1]. The prevalence of small airways dysfunction (SAD) ranges from 50–90% and correlates with COPD patient symptoms [2]. SAD is usually well-established before conventional spirometry is abnormal [3], contributes to patient quality-of-life burden [4], and disease exacerbations [5].

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Publication Details

Journal
European Respiratory Journal
Published
2025-11-27
DOI
https://doi.org/10.1183/13993003.01326-2025
Primary Topic
Chronic Obstructive Pulmonary Disease (COPD) Research
Type
article
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article

Whole lung directed anti-muscarinic therapy improves small airway dysfunction in COPD patients

Sally Meah, Omar S. Usmani, Vincent Mak, Dimitrios Toumpanakis et al.
European Respiratory Journal
Chronic Obstructive Pulmonary Disease (COPD) Research
article

Whole lung directed anti-muscarinic therapy improves small airway dysfunction in COPD patients

Sally Meah, Omar S. Usmani, Vincent Mak, Dimitrios Toumpanakis, Martyn F. Biddiscombe
article en

Abstract

<title>Extract</title> Small airways disease is a key feature of chronic obstructive pulmonary disease (COPD) that often precedes emphysema and is the major site of airflow limitation [1]. The prevalence of small airways dysfunction (SAD) ranges from 50–90% and correlates with COPD patient symptoms [2]. SAD is usually well-established before conventional spirometry is abnormal [3], contributes to patient quality-of-life burden [4], and disease exacerbations [5].

European Respiratory JournalVol. 67(2)
Imperial College Healthcare NHS Trust (GB), National and Kapodistrian University of Athens (GR), Charing Cross Hospital (GB), Lung Institute (US), Imperial College London (GB)
Openalex Percentile: Top 45%
Chronic Obstructive Pulmonary Disease (COPD) Research
DOIOpen Access PDFOpenAlex
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Whole lung directed anti-muscarinic therapy improves small airway dysfunction in COPD patients — Sally Meah, Omar S. Usmani, et al. · European Respiratory Journal (2025) | TGRS Research Map | TGRS