Lower lobe mucus plug distribution and future respiratory exacerbations in tobacco-exposed individuals with and without COPD
<title>Extract</title> Mucus plugs (MPs) on chest computed tomography (CT) are highly prevalent and are associated with increased respiratory symptoms[1], worse lung function[1], increased mortality[2] and acute exacerbations[3] among individuals with chronic obstructive pulmonary disease (COPD). Whether mucus plug <italic>distribution</italic> in the upper <italic>versus</italic> lower lobes differentially impacts future respiratory exacerbations (REs), both within established COPD and among non-obstructed tobacco-exposed individuals, has been incompletely explored.
Authors
- Raúl San Jośe Estépar (ORCID: https://orcid.org/0000-0002-3677-1996)
- Michael H. Cho (ORCID: https://orcid.org/0000-0002-4907-1657)
- Alejandro A. Díaz (ORCID: https://orcid.org/0000-0001-5037-2919)
- Sushilkumar K. Sonavane (ORCID: https://orcid.org/0000-0001-8823-7261)
- Scott Grumley (ORCID: https://orcid.org/0000-0001-8285-2423)
- Andrew Yen (ORCID: https://orcid.org/0000-0003-3456-0375)
- Mohd Zahid (ORCID: https://orcid.org/0000-0001-7059-1879)
- Muhammad Usman Aziz (ORCID: https://orcid.org/0000-0002-7246-650X)
- Wei Wang (ORCID: https://orcid.org/0000-0001-9243-8672)
- Pietro Nardelli (ORCID: https://orcid.org/0000-0003-4280-558X)
- Emily S. Wan (ORCID: https://orcid.org/0000-0002-4126-2467)
- Padma P. Manapragada (ORCID: https://orcid.org/0000-0003-0915-0550)
- Sofia K. Mettler (ORCID: https://orcid.org/0000-0002-7553-1346)
- Mostafa Abozeed (ORCID: https://orcid.org/0000-0003-3830-0757)
- Ruchita Borgaonkar (ORCID: https://orcid.org/0009-0003-2947-2757)
- Monica Iturrioz-Campo
Institutions
- Brigham and Women's Hospital (US)
- University of San Diego (US)
- VA Boston Healthcare System (US)
- WinnMed (US)
- University of Alabama at Birmingham (US)
- University of California San Diego (US)
- Nemours Children’s Clinic (US)
- Mayo Clinic in Florida (US)
- Nemours Children's Clinic (US)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1183/13993003.00523-2025
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00