Predicting Toxicities and Survival Outcomes in De Novo Metastatic Hormone-Sensitive Prostate Cancer Using Clinical Features, Routine Blood Tests and Their Early Variations
The integration of conventional prognostic factors with the detection of significant changes in vital signs and blood tests occurring early during systemic treatment in patients with de novo mHSPC may enhance patient stratification and improve prediction of survival outcomes. Multicenter validation studies are needed to confirm these results.
Authors
- Sara Merler (ORCID: https://orcid.org/0000-0002-8691-6284)
- Silke Gillessen (ORCID: https://orcid.org/0000-0001-5746-6555)
- Fabio Turco (ORCID: https://orcid.org/0000-0003-3111-7888)
- Lorenzo Ruinelli (ORCID: https://orcid.org/0000-0002-9144-2570)
- Daniele Brenna (ORCID: https://orcid.org/0000-0001-8742-935X)
- Martino Pedrani (ORCID: https://orcid.org/0000-0002-8502-8226)
- Ursula Vogl (ORCID: https://orcid.org/0000-0002-2046-4246)
- Ricardo Pereira Mestre (ORCID: https://orcid.org/0000-0002-3123-3697)
- Maria Ausiliatrice Puglisi (ORCID: https://orcid.org/0000-0002-8562-9902)
- Giovanna Pecoraro (ORCID: https://orcid.org/0009-0003-6743-6933)
- Carlo Clerici (ORCID: https://orcid.org/0000-0002-1071-343X)
- Luigi Tortola (ORCID: https://orcid.org/0000-0002-8480-2080)
- Giuseppe Salfi (ORCID: https://orcid.org/0000-0003-4953-0339)
- Caroline-Claudia Erhart
- Amos Colombo (ORCID: https://orcid.org/0009-0000-3638-8973)
Institutions
- University of Messina (IT)
- Ospedale di Bolzano (IT)
- Ente Ospedaliero Cantonale (CH)
- Institute of Oncology Research (CH)
- Federico II University Hospital (IT)
- Università della Svizzera italiana (CH)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Cancers
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3390/cancers17233806
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00