Endothelial cells as early therapeutic targets in chronic obstructive pulmonary disease: Insights into Tongxinluo’s multiple protective mechanisms against cigarette smoke-induced lung injury
Our findings underscore the innovative potential of targeting PMECs for early COPD intervention through the integration of single-cell RNA sequencing and spatial transcriptomics. Furthermore, we demonstrate the novel therapeutic potential of TXL in mitigating lung injury and promoting endothelial-mediated epithelial regeneration as well as PMEC proliferation via the Apelin/APJ/p38MAPK pathway providing a novel perspective for COPD intervention.
Authors
- Zhenhua Jia (ORCID: https://orcid.org/0000-0001-5132-1099)
- Yuming Hao
- Yuanyuan Hao (ORCID: https://orcid.org/0000-0001-8573-5433)
- Yunlong Hou (ORCID: https://orcid.org/0000-0002-6989-8221)
- Yi Liu (ORCID: https://orcid.org/0009-0007-5858-9056)
- Ningxin Han (ORCID: https://orcid.org/0000-0001-8082-690X)
- Tian-Dong Che
- Mingyu Xiong
- Xiaoqi Wang (ORCID: https://orcid.org/0000-0002-2700-1017)
- Hui Qi
- Yan Ma (ORCID: https://orcid.org/0009-0004-2546-3340)
- Yujie Yin (ORCID: https://orcid.org/0000-0002-9878-5568)
- Yaru Wei
- Huixin Li
- Jing Guo (ORCID: https://orcid.org/0009-0005-8497-9758)
Institutions
- Hebei Medical University (CN)
- Hebei Yiling Hospital (CN)
- Hebei University of Chinese Medicine (CN)
- Hangzhou DAC Biotech (China) (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1016/j.phymed.2025.157600
- Primary Topic
- Apelin-related biomedical research
- Type
- article
- Field-Weighted Citation Impact
- 0.00