Differential glomerular expression patterns of Th17-related cytokines in Mexican patients with lupus nephritis
<b>Objective:</b> We aimed to investigate <i>in-situ</i> expression of interleukin IL-17A, IL-21, IL-22, and IL-35 in lupus nephritis (LN).<b>Methods:</b> A cross-sectional study using immunohistochemistry (IHC) in renal biopsy to detect <i>in-situ</i> expression of interleukin IL-17 family and IL-35 from 20 Mexican patients with moderate to severe LN. <b>Results:</b> We found predominant expression of IL-17A and IL-21 in the glomerular region. IL-22 was detected in the tubulointerstitium and inflammatory aggregates, notwithstanding IL-21 and IL-35 in fibrotic and atrophic tubules. A positive correlation was found between IL-17A expression in the glomerulus and tubulointerstitium with creatinine, urea, and blood urea nitrogen levels, whereas IL-35 expression decreases in the presence of proteinuria. IL-21 was high in disease activity and severity versus IL-35 that decreased in systemic lupus erythematosus (SLE) disease activity.<b>Conclusions:</b> These findings provide evidence for the compartment-specific expression in LN of Th17-related cytokines and IL-35 in Mexican patients.
Authors
- Andrea Aguilar-Vázquez
- Óscar Pizano-Martínez (ORCID: https://orcid.org/0000-0003-3635-7071)
- Edy David Rubio Arellano (ORCID: https://orcid.org/0000-0002-3337-7934)
- Sergio Duran-Barragán (ORCID: https://orcid.org/0000-0003-4581-7260)
- Leonardo Pazarín–Villaseñor (ORCID: https://orcid.org/0000-0001-8755-9058)
- Erika Aurora Martínez-García
- Lilia Andrade-Ortega
- Beatriz Teresita Martín-Márquez (ORCID: https://orcid.org/0000-0002-6756-4316)
- Arcelia Llamas-García (ORCID: https://orcid.org/0000-0003-4140-1508)
- Arisbeth Villanueva-Pérez
- Felipe Pérez-Vázquez (ORCID: https://orcid.org/0000-0003-0697-9371)
- Javier Soto-Vargas (ORCID: https://orcid.org/0000-0003-3623-0716)
- Cynthia-Alejandra Gomez-Rios
- Mónica Vázquez-Del Mercado (ORCID: https://orcid.org/0000-0002-3823-4676)
- Efrain Chavarría-Ávila (ORCID: https://orcid.org/0000-0001-7588-3870)
- Christian Juarez-Gomez (ORCID: https://orcid.org/0009-0006-1247-3341)
- Maribell Cabrera-López
- Edgar-Federico Quirarte-Tovar
- Ligia Magaña-García
- Itzel-Yoselin Arteaga-Gallegos
- Judith-Alejandra Esparza-Michel
Institutions
- Universidad de Guadalajara (MX)
- Hospital Civil de Guadalajara (MX)
- Hospital General De Zona (MX)
- Centro Diagnostico Italiano (IT)
- Office of the Secretary of Health and Human Services (US)
- Institute for Social Security and Services for State Workers (MX)
Publication Details
- Journal
- Lupus
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1177/09612033251405359
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00