Molecular subtyping and a seven-gene immune signature reveal heterogeneity in tumor microenvironment and prognosis of lung adenocarcinoma
This study identified three LUAD subtypes with distinct immune characteristics and constructed a seven-gene prognostic model. This model correlates with immune checkpoint and chemotherapy sensitivity, providing new targets and strategies for clinical diagnosis and treatment.
Authors
- Xian Gao (ORCID: https://orcid.org/0000-0001-7937-5478)
- Zhongfeng Cui
- Hongzhi Li (ORCID: https://orcid.org/0000-0002-8662-5145)
- Jing Su (ORCID: https://orcid.org/0009-0007-9636-1714)
- Guangming Li (ORCID: https://orcid.org/0000-0003-2286-7679)
- Xinglan Cao
- Chengde Chen
Institutions
- The Sixth People's Hospital of Zhengzhou (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s40001-025-03544-w
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00