Adhesion of Immunoglobulins to Band3 Promotes Increased Erythrocyte Sedimentation Rate in Multiple Myeloma
Decreased sialic acid increases the adhesion of RBC membranes to immunoglobulins leading to an increased erythrocyte sedimentation rate (ESR). The increase in reactive oxygen species (ROS) damages the sialic acid glycosyl chains on the surface of RBC membrane proteins, causing the membrane proteins to be overexposed to the plasma environment due to the loss of sialic acid coverage. Immunoglobulins in plasma adhere to RBC membrane Band3 extracellularly exposed peptides through intermolecular interactions. The reduction of sialic acid causes a weakening of the RBC membrane negative charge barrier and the adhesion of immunoglobulins further destabilises the suspension of RBCs, resulting in a rapid addition of ESR to multiple myeloma.
Authors
- Hengrui Liu (ORCID: https://orcid.org/0000-0002-5369-3926)
- Sicheng Bian (ORCID: https://orcid.org/0000-0001-9527-2102)
- Xialin Zhang (ORCID: https://orcid.org/0000-0002-2234-3106)
- Ruo Wang (ORCID: https://orcid.org/0000-0002-0676-5085)
- Xufeng Huang (ORCID: https://orcid.org/0000-0001-9941-3355)
- Yanhong Tan (ORCID: https://orcid.org/0000-0002-6257-8655)
- Zhengrui Li (ORCID: https://orcid.org/0000-0003-4923-0088)
- Zhuanghui Hao
- Jiangxia Cui
- Xingpeng Bu (ORCID: https://orcid.org/0000-0003-0494-5450)
- Qi Wang (ORCID: https://orcid.org/0000-0002-5287-6050)
- Yinghua Li (ORCID: https://orcid.org/0000-0002-8060-8221)
- Hongwei Wang (ORCID: https://orcid.org/0000-0002-2902-591X)
- Lili Sun (ORCID: https://orcid.org/0000-0003-3809-0374)
- Leilei Lin
- Chang Qu (ORCID: https://orcid.org/0000-0002-5494-3245)
- Chongzhi Bai (ORCID: https://orcid.org/0000-0002-6293-6141)
Institutions
- Qingdao University (CN)
- Fujian Medical University (CN)
- Harbin Medical University (CN)
- Shanxi Medical University (CN)
- Shanghai Jiao Tong University (CN)
- University of Cambridge (GB)
- Yuhuangding Hospital (CN)
- Bridge University (SS)
- Shanxi Province Hospital of Traditional Chinese Medicine (CN)
- Beijing Hospital (CN)
- Shanxi Academy of Building Research (CN)
- First Hospital of Shanxi Medical University (CN)
- Second Hospital of Shanxi Medical University (CN)
- Fujian Provincial Hospital (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
- MetroHealth Medical Center (US)
- Shanxi Academy of Medical Sciences (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Cell Proliferation
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1111/cpr.70149
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Harbin Medical University
- National Natural Science Foundation of China
- Shanxi Medical University