Oxidative stress-induced proinflammatory secretion from retinal pigment epithelium disrupts NAD+ metabolism via CD38 on macrophages leading to immune microenvironment dysregulation
OS in the RPE drives metabolic reprogramming in macrophages via cytokine secretion, altering their transcriptional profiles and cellular functions. Our study established CD38 as a promising therapeutic target for modulating macrophage-driven pathology in OS-associated ocular disorders.
Authors
- Zhongqi Wan
- Ruoyi Lin
- Jian‐Qiang Ma (ORCID: https://orcid.org/0009-0007-8935-4161)
- Jing Yu (ORCID: https://orcid.org/0000-0002-4899-0467)
- Wenting Cai (ORCID: https://orcid.org/0000-0002-2880-302X)
- Yunjian Luo (ORCID: https://orcid.org/0000-0002-7358-5797)
- Lei Jiang (ORCID: https://orcid.org/0000-0002-5143-9262)
- Zihang Xu (ORCID: https://orcid.org/0009-0003-5576-2846)
- Liang Feng (ORCID: https://orcid.org/0000-0002-4900-3443)
- Chengyu Hu (ORCID: https://orcid.org/0000-0002-8097-1434)
- Yan Wu (ORCID: https://orcid.org/0000-0001-7947-314X)
Institutions
- Pudong Medical Center (CN)
- Shanghai Tenth People's Hospital (CN)
Publication Details
- Journal
- Free Radical Biology and Medicine
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1016/j.freeradbiomed.2025.11.041
- Primary Topic
- Calcium signaling and nucleotide metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00