A fibroblast-specific gene signature as a therapeutic target for glioblastoma developed based on the characteristics of tumor microenvironment
We constructed a RiskScore model for predicting the survival outcomes based on fibroblasts-related genes. These findings highlighted the role of fibroblasts in GBM development and offered six potential therapeutic targets (VWA1, DUSP6, LOXL1, IGFBP4, CYGB, and ZIC3) for GBM treatment. Additionally, immune infiltration analysis and drug sensitivity prediction further supported the model's utility in guiding personalized treatment of GBM.
Authors
- Jiaxuan Zhao (ORCID: https://orcid.org/0009-0009-9348-0472)
- Tongcun Zhang (ORCID: https://orcid.org/0000-0001-5350-2993)
- Yeting Cui (ORCID: https://orcid.org/0009-0000-0590-0006)
- Mingyue Zhao (ORCID: https://orcid.org/0000-0002-7340-1345)
- Nan Liu (ORCID: https://orcid.org/0000-0002-4759-1448)
- Xiaofei Hu (ORCID: https://orcid.org/0000-0002-0380-4587)
- Yanyang Tu (ORCID: https://orcid.org/0000-0002-8970-7314)
Institutions
- Tianjin University of Science and Technology (CN)
- Army Medical University (CN)
- Southwest Hospital (CN)
- Huizhou Central People's Hospital (CN)
- Air Force General Hospital PLA (CN)
- Wuhan University of Science and Technology (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s40001-025-03528-w
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00