Retinomics: a window to multidisease prediction using retinal biomarkers from routine eye imaging
Retinomics universally enhanced disease prediction, with marked gains for conditions like cardiovascular and metabolic disorders. The onset of presbyopia (~ 50 years)-a common trigger for eye exams-aligns with escalating chronic disease risks, suggesting an opportunity to leverage routine eye care for broader health assessment. While requiring further validation, this approach demonstrates the potential to enhance health screening efficiency using existing ophthalmic infrastructure, offering particular value for resource-limited settings.
Authors
- Danli Shi (ORCID: https://orcid.org/0000-0001-6094-137X)
- Mayinuer Yusufu (ORCID: https://orcid.org/0000-0002-4860-0318)
- Xianwen Shang (ORCID: https://orcid.org/0000-0001-6143-9349)
- Matthew J. Burton (ORCID: https://orcid.org/0000-0003-1872-9169)
- Shanshan Jin (ORCID: https://orcid.org/0000-0002-8515-0352)
- Lei Zhang (ORCID: https://orcid.org/0000-0003-2343-084X)
- Mingguang He (ORCID: https://orcid.org/0000-0002-6664-3442)
Institutions
- Beijing Tongren Hospital (CN)
- Hong Kong Polytechnic University (HK)
- The University of Melbourne (AU)
- Hong Kong Eye Hospital (CN)
- London School of Hygiene & Tropical Medicine (GB)
- Centre for Eye Research Australia (AU)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s12916-025-04450-y
- Citations
- 1
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- Hong Kong Polytechnic University
- Joint Research Centre