Management of endothelial dysfunction in septic shock: role of albumin administration

Sepsis is a significant global health issue, with high morbidity, mortality, and economic burden. Its definition has evolved, with the latest Sepsis-3 criteria emphasizing life-threatening organ dysfunction due to a dysregulated host response. Endothelial dysfunction plays a critical role in sepsis pathogenesis, characterized by increased permeability and inflammatory responses. Human serum albumin, the most abundant protein in the bloodstream, is essential for maintaining oncotic pressure and endothelial integrity. This narrative review provides an overview of endothelial changes during sepsis and their impact on organ damage. We also explore the role of albumin administration in managing endothelial dysfunction in sepsis and discuss the available preclinical and clinical evidence.

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Publication Details

Journal
Journal of Intensive Care
Published
2025-11-27
DOI
https://doi.org/10.1186/s40560-025-00836-5
Citations
2
Primary Topic
Trauma, Hemostasis, Coagulopathy, Resuscitation
Type
article
Field-Weighted Citation Impact
3.09

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article

Management of endothelial dysfunction in septic shock: role of albumin administration

Michelle S. Chew, Ignacio Martín‐Loeches, Lene Russell, Andrew Conway Morris et al.
2 citations
Journal of Intensive Care
Trauma, Hemostasis, Coagulopathy, Resuscitation
3.09
article

Management of endothelial dysfunction in septic shock: role of albumin administration

Michelle S. Chew, Ignacio Martín‐Loeches, Lene Russell, Andrew Conway Morris, Sharon Einav, Alejandro Rodrı́guez, Marc Léone
article en
2 citations

Abstract

Sepsis is a significant global health issue, with high morbidity, mortality, and economic burden. Its definition has evolved, with the latest Sepsis-3 criteria emphasizing life-threatening organ dysfunction due to a dysregulated host response. Endothelial dysfunction plays a critical role in sepsis pathogenesis, characterized by increased permeability and inflammatory responses. Human serum albumin, the most abundant protein in the bloodstream, is essential for maintaining oncotic pressure and endothelial integrity. This narrative review provides an overview of endothelial changes during sepsis and their impact on organ damage. We also explore the role of albumin administration in managing endothelial dysfunction in sepsis and discuss the available preclinical and clinical evidence.

Journal of Intensive CareVol. 14(1)
Linköping University (SE), Karolinska University Hospital (SE), Hebrew University of Jerusalem (IL), Trinity College Dublin (IE), Aix-Marseille Université (FR), Gentofte Hospital (DK), Maccabi Healthcare Services (IL), Assistance Publique Hôpitaux de Marseille (FR), Hospital Universitari Joan XXIII de Tarragona (ES), St. James's Hospital (IE), Addenbrooke's Hospital (GB)
Grifols, Medical Research Council
Openalex Percentile: Top 8%
Trauma, Hemostasis, Coagulopathy, Resuscitation
3.09
DOIOpen Access PDFOpenAlex
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