Spontaneous regression of metastatic disease after palliative debulking surgery for heavily pre-treated extraskeletal myxoid chondrosarcoma: A case report
Spontaneous regression of metastatic disease in the setting of advanced cancer is a poorly understood clinical phenomenon which occurs infrequently across all tumour types but exceptionally rarely in soft tissue sarcomas. Extraskeletal myxoid chondrosarcoma (EMC) is a rare subtype of soft tissue sarcoma that is poorly responsive to systemic treatment, providing limited options to patients with metastatic disease. We report spontaneous regression of lung metastases in a patient with EMC after re-resection of the primary tumour, which was performed with palliative intent for symptom control after multiple lines of systemic treatment. The patient has remained disease-free and is now more than 5 years post-surgery. To our knowledge, this is the first described case of spontaneous regression of metastatic disease following resection of a primary tumour in a patient with EMC.
Authors
- Kenneth J. Feeley (ORCID: https://orcid.org/0000-0002-3618-1144)
- Anna Keogh (ORCID: https://orcid.org/0000-0002-2187-1126)
- John Crown (ORCID: https://orcid.org/0000-0002-3125-7613)
- Aurélie Fabre (ORCID: https://orcid.org/0000-0001-8176-1386)
- Hailey Carroll (ORCID: https://orcid.org/0000-0002-3052-3975)
- Deirdre O’Mahony (ORCID: https://orcid.org/0000-0001-6987-445X)
- Richard Bambury (ORCID: https://orcid.org/0000-0002-2189-6972)
- Asıf Muneer (ORCID: https://orcid.org/0000-0003-2958-1614)
- Simon Barry (ORCID: https://orcid.org/0009-0007-5042-1558)
- Gary O’Toole
Institutions
- University College Dublin (IE)
- University College London Hospitals NHS Foundation Trust (GB)
- University College Cork (IE)
- Bon Secours Hospital (US)
- Cappagh National Orthopaedic Hospital (IE)
- Cork University Hospital (IE)
- St Vincent’s Private Hospital Sydney (AU)
- St. Vincent's University Hospital (IE)
- University College London (GB)
Publication Details
- Journal
- Rare Tumors
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1177/20363613251392654
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00