Long-term effect of neoadjuvant denosumab treatment in high-risk early breast cancer (GeparX)
Denosumab as part of neoadjuvant therapy, although not improving the pCR rate, significantly reduced the risk of distant relapses. Other long-term outcome parameters did not differ between the treatment arms. TNBC patients, especially when not achieving pCR, seem to benefit from weekly nPac.
Authors
- J. Huober
- Johannes Holtschmidt (ORCID: https://orcid.org/0000-0002-2723-1154)
- M. Just
- Theresa Link (ORCID: https://orcid.org/0000-0002-2229-7867)
- Peter A. Fasching (ORCID: https://orcid.org/0000-0003-4885-8471)
- Christine Solbach (ORCID: https://orcid.org/0000-0001-8284-3199)
- Natalie Filmann (ORCID: https://orcid.org/0000-0003-0424-2317)
- Vesna Bjelic‐Radisic (ORCID: https://orcid.org/0000-0002-3749-4775)
- Claus Hanusch
- Jens‐Uwe Blohmer (ORCID: https://orcid.org/0000-0002-7969-250X)
- M. Untch
- Carsten Denkert
- Knut Engels (ORCID: https://orcid.org/0000-0002-8685-3797)
- Pauline Wimberger (ORCID: https://orcid.org/0000-0002-7380-577X)
- Mattea Reinisch (ORCID: https://orcid.org/0000-0002-1381-8595)
- Marc Thill (ORCID: https://orcid.org/0000-0002-8800-8044)
- Valentina Nekljudova (ORCID: https://orcid.org/0000-0002-2801-7387)
- Sibylle Loibl (ORCID: https://orcid.org/0000-0001-6488-4958)
- Andreas Schneeweiß (ORCID: https://orcid.org/0000-0002-2429-4512)
- Oliver Stötzer
- Kerstin Rhiem
Institutions
- Goethe University Frankfurt (DE)
- Philipps University of Marburg (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Universitätsklinikum Gießen und Marburg (DE)
- Kantonsspital St. Gallen (CH)
- University Hospital Heidelberg (DE)
- National Center for Tumor Diseases (DE)
- Helios Universitätsklinikum Wuppertal (DE)
- German Breast group (DE)
- University Hospital Frankfurt (DE)
- Praxis für Hämatologie und Onkologie (DE)
- Rotkreuzklinikum München (DE)
- Agaplesion Markus Hospital (DE)
- Centrum für Integrierte Onkologie (DE)
- Comprehensive Cancer Center Erlangen (DE)
- University Hospital Cologne (DE)
- Helios Hospital Berlin-Buch (DE)
- University Medical Centre Mannheim (DE)
- University Hospital Carl Gustav Carus (DE)
- Zentrum für Pathologie und Zytodiagnostik (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105915
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00