CXCL6 Orchestrates Macrophage-Driven Inflammation in Diabetic Kidney Disease and Represents a Druggable Target
Our study uncovers CXCL6 as a key mediator of tubulointerstitial inflammation in DKD, linking tubular injury to immune cell recruitment and cytokine-driven damage. Furthermore, we identify Sal-B as a promising therapeutic candidate targeting this newly characterized pathway, offering potential for diagnostic and therapeutic advancement in DKD.
Authors
- Lingzhi Wu
- Yuxiang Sun (ORCID: https://orcid.org/0000-0002-6656-3733)
- Hui Peng (ORCID: https://orcid.org/0000-0002-0220-3616)
- Zhaoyong Hu (ORCID: https://orcid.org/0000-0003-4171-3587)
- Yuebo Huang
- Dongxuan Wu (ORCID: https://orcid.org/0009-0001-2779-8310)
- Juan Sun
- Dandan Guo (ORCID: https://orcid.org/0000-0002-6829-1356)
- Hongchun Lin
- Pan Zhou (ORCID: https://orcid.org/0000-0002-7105-6808)
- Hu Zhou (ORCID: https://orcid.org/0000-0001-6295-8212)
Institutions
- Sun Yat-sen University (CN)
- Baylor College of Medicine (US)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Kidney Diseases
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1159/000548806
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00