Reproducible Identification of <i>Staphylococcus aureus</i> Bacteremia Clinical Subphenotypes
We have reproducibly identified five clinical subphenotypes of SAB in observational cohorts including diverse bacterial genetic lineages and a cohort with a high prevalence of MRSA and USA300 bacteremia. These robustly reproducible clinical subphenotypes provide a framework to rationalize the heterogeneity intrinsic to SAB.
Authors
- Robin Soetekouw
- Zsuzsa Bakk (ORCID: https://orcid.org/0000-0001-9352-4812)
- Simon Dewar
- David H. Dockrell (ORCID: https://orcid.org/0000-0002-2718-4861)
- Jan A. Veenstra (ORCID: https://orcid.org/0000-0002-2783-0018)
- Annette C. Westgeest (ORCID: https://orcid.org/0000-0002-0648-3555)
- Bjorn L. Herpers (ORCID: https://orcid.org/0000-0003-1632-8302)
- Vance G. Fowler (ORCID: https://orcid.org/0000-0002-8048-0897)
- Jan M. Prins (ORCID: https://orcid.org/0000-0002-5415-8933)
- Mark de Boer (ORCID: https://orcid.org/0000-0002-5009-6499)
- Maaike Swets (ORCID: https://orcid.org/0000-0003-0901-9560)
- Marc J. M. Bonten (ORCID: https://orcid.org/0000-0002-9095-9201)
- Thomas W. van der Vaart (ORCID: https://orcid.org/0000-0002-5873-0474)
- Rebecca Sutherland (ORCID: https://orcid.org/0000-0001-5214-9630)
- Geert H. Groeneveld (ORCID: https://orcid.org/0000-0001-6529-1396)
- Jean-Francois Jabbour (ORCID: https://orcid.org/0000-0002-0214-8290)
- Felicia Ruffin (ORCID: https://orcid.org/0000-0003-2176-6462)
- Clark D Russell (ORCID: https://orcid.org/0000-0002-9873-8243)
- Luke Tysall (ORCID: https://orcid.org/0000-0002-0966-3877)
- Rachel E. Korn (ORCID: https://orcid.org/0009-0007-2239-0870)
- Rogier R. Jansen
- Jan T. M. van der Meer
- G. van Twillert
- Wouter Rozemeijer
- Priscilla La (ORCID: https://orcid.org/0009-0005-7724-4753)
Institutions
- Leiden University (NL)
- Duke University (US)
- University of Applied Sciences Leiden (NL)
- Leiden University Medical Center (NL)
- Western General Hospital (GB)
- Edinburgh Royal Infirmary (GB)
- Clinical Research Institute (US)
- Medisch Centrum Haaglanden (NL)
- Amsterdam Neuroscience (NL)
- Centre for Inflammation Research (GB)
- Amsterdam University of Applied Sciences (NL)
- University of Amsterdam (NL)
- University of Edinburgh (GB)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1093/cid/ciaf655
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00