A Brief History of the Use of Insecticides in Brazil to Control Vector-Borne Diseases, and Implications for Insecticide Resistance

In Brazil, public health programs have relied predominantly on chemical insecticides to control <i>Aedes aegypti</i>, <i>Anopheles</i> spp., <i>Culex quinquefasciatus</i>, triatomines, and phlebotomines. Rising vector-borne disease incidence and insecticide resistance (IR) call for a critical appraisal of historical and current control practices. This literature review compiles secondary data produced from 1901 to 2024 obtained from Medline/PubMed, Google Scholar, and governmental notes and reports. Brazil's vector control progressed from organochlorines (e.g., DDT) to organophosphates, carbamates, pyrethroids, insect growth regulators, microbial larvicides (Bti and Lsp), spinosad, and recently formulations with dual active-ingredient. <i>Ae. aegypti</i> showed widespread resistance to temephos and pyrethroids, decreased susceptibility to pyriproxyfen, and no documented Bti resistance. <i>Anopheles</i> spp. exhibited low to moderate resistance to pyrethroids. <i>Cx. quinquefasciatus</i> resistance is likely influenced by collateral exposure from <i>Aedes</i> control and domestic use. Regarding triatomines and phlebotomines, there was a predominant reliance on pyrethroids; most studies indicate their susceptibility to these compounds. In short, Brazil's century-long, insecticide-centric strategy has delivered episodic gains but fostered <i>Aedes aegypti</i> resistance. For other species, for which there is no dedicated program for a long period, data on resistance are scarce or nonexistent. Sustainable progress requires strengthened, nationwide IR surveillance and entomological mapping to coordinate cross-program actions.