The pattern of gene amplification of members of the Plasmodium vivax erythrocyte binding-like proteins family across the Amazon rainforest
This study identifies dbp and ebp2 gene amplifications in P. vivax isolates from the Amazon rainforest, with regional CNV variation but no association with any DARC-positive genotype. These findings support further investigation into gene amplifications to elucidate their biological and immunological significance in DARC-positive populations.
Authors
- Flora Satiko Kano (ORCID: https://orcid.org/0000-0002-2364-9772)
- Francis B. Ntumngia (ORCID: https://orcid.org/0000-0001-9867-3534)
- Cor Jésus Fernandes Fontes (ORCID: https://orcid.org/0000-0003-2756-0588)
- Gabriela M. Fernandes
- Karla de Sena Guedes (ORCID: https://orcid.org/0000-0001-8508-575X)
- John H. Adams (ORCID: https://orcid.org/0000-0003-3707-7979)
- Taís Nóbrega de Sousa (ORCID: https://orcid.org/0000-0002-6874-9427)
- Luzia H. Carvalho (ORCID: https://orcid.org/0000-0001-5822-4187)
- Bruno A. M. Sanchez (ORCID: https://orcid.org/0000-0001-9097-0112)
Institutions
- University of South Florida (US)
- Universidade Federal de Mato Grosso (BR)
- Center for Global Health (US)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s12936-025-05690-2
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00