Novel dual AMPK/NRF2 activation by leucocyanidin from Hawthorn (Crataegus) for mitochondria repair-Targeted therapy of hepatic steatosis
These coordinated mechanisms reestablished hepatic lipid homeostasis, positioning Leuc as a promising dual-target natural compound for MASLD intervention through simultaneous AMPK/NRF2 activation.
Authors
- Yunheng Li (ORCID: https://orcid.org/0000-0002-5622-7787)
- Bo Yang (ORCID: https://orcid.org/0000-0002-8989-9387)
- Minghua Ye
- Peihua Luo (ORCID: https://orcid.org/0000-0002-6576-2052)
- Qiaojun He (ORCID: https://orcid.org/0000-0002-0104-6989)
- Xiaochun Yang (ORCID: https://orcid.org/0000-0002-2248-5235)
Institutions
- Zhejiang Lab (CN)
- ZheJiang Institute For Food and Drug Control (CN)
- Zhejiang University of Technology (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1016/j.phymed.2025.157614
- Citations
- 3
- Primary Topic
- Botanical Studies and Applications
- Type
- article
- Field-Weighted Citation Impact
- 5.25