Human umbilical cord mesenchymal stem cells attenuate liver fibrosis in mice and inhibit hepatic stellate cell activation by secreting soluble factors
IP-administered therapeutic UC-MSCs preferentially accumulate in the liver and effectively prevent and reverse liver fibrosis in mice, while inhibiting hepatic stellate cell activation in vitro. The antifibrotic effects in vivo are likely primarily mediated by excreted soluble factors rather than extracellular vesicles.
Authors
- Klaas Nico Faber (ORCID: https://orcid.org/0000-0001-8893-3312)
- Martin C. Harmsen (ORCID: https://orcid.org/0000-0002-7128-2741)
- Pingnan Sun (ORCID: https://orcid.org/0000-0002-3325-8062)
- Ruyi Mei
- Han Moshage (ORCID: https://orcid.org/0000-0002-4764-0246)
- Junyu Wang (ORCID: https://orcid.org/0000-0003-4605-2423)
- Qi Zhou (ORCID: https://orcid.org/0000-0002-0441-584X)
- Ke Cheng
- Janette Heegsma
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Shantou University (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Shantou University Medical College (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s13287-025-04812-6
- Citations
- 1
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.32