Cerebrospinal fluid visinin-like protein, glial cell line-derived neurotrophic factor, and cadherin-6 alterations in pregnancy complications
CSF biomarker alterations in complicated pregnancies, predominantly driven by hypertensive disorders, suggest neuroinflammatory activation and compromised neuroprotection. The heterogeneous grouping of pathophysiologically distinct complications constitutes a primary methodological limitation. These preliminary findings necessitate validation through adequately powered, disease-specific investigations before clinical translation.
Authors
- Emine Yilmaz Güler
- Numan Çim (ORCID: https://orcid.org/0000-0003-0983-3204)
- Filiz Yarşılıkal Güleroğlu (ORCID: https://orcid.org/0000-0003-4577-3368)
- Hatice Argun Atalmış (ORCID: https://orcid.org/0000-0003-0432-8786)
- Ali Çetin (ORCID: https://orcid.org/0000-0002-5767-7894)
- Sinem Tekin (ORCID: https://orcid.org/0000-0003-4183-6472)
- Pelin Kulan
Institutions
- Haseki Eğitim ve Araştırma Hastanesi (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Universidad CES (CO)
- Türk Anesteziyoloji ve Reanimasyon Derneği (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s40001-025-03584-2
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00