Gut microbiota metabolites and key target molecules in allergic rhinitis: a multi-omics study of gut-nose axis regulation via the inflammation-metabolism network
This study provides the first systematic exploration of the "gut-nasal" metabolic axis in AR at a multi-level molecular network level, offering novel perspectives on the disease's underlying mechanisms. The identified targets and candidate drugs provide a valuable foundation for developing new therapeutic strategies, warranting further experimental validation for potential clinical translation.
Authors
- Mengqi Zhao (ORCID: https://orcid.org/0000-0002-1230-2116)
- Yulan Zeng (ORCID: https://orcid.org/0000-0002-6415-1794)
- Jingqi Zhang
- Meiyi Sun
- Hui Xie (ORCID: https://orcid.org/0000-0001-5084-6168)
- Chuanyu Wu (ORCID: https://orcid.org/0000-0003-4951-6502)
- Tao Guo (ORCID: https://orcid.org/0000-0001-8556-7564)
- Liping Lin
- Zhiqing Liu (ORCID: https://orcid.org/0000-0002-0725-1430)
- Ya Yu
Institutions
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fmicb.2025.1702518
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00