Prehospital plasma transfusion versus standard of care following traumatic injury: a review of the systematic reviews and a meta-analysis

The overall pooled analysis revealed no significant benefit to PHP transfusion in trauma patients; however, sensitivity analyses showed a significant association of PHP and lower 24-hour mortality. PHP did not significantly decrease vasopressor use or late mortality; however, it may reduce the total use of RBCs in the first 24 h. Regarding safety, the review findings should be interpreted cautiously. Umbrella review was not conducted due to the heterogeneity and inconsistent inclusion criteria and outcomes. Further studies are needed to address the inconsistency in the existing evidence and determine whether PHP transfusion should be recommended for trauma patients with clearer and standardized endpoints and adverse event reporting.

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Publication Details

Journal
European Journal of Trauma and Emergency Surgery
Published
2025-11-27
DOI
https://doi.org/10.1007/s00068-025-03033-z
Citations
1
Primary Topic
Trauma, Hemostasis, Coagulopathy, Resuscitation
Type
article
Field-Weighted Citation Impact
1.55
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Prehospital plasma transfusion versus standard of care following traumatic injury: a review of the systematic reviews and a meta-analysis

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1 citations
European Journal of Trauma and Emergency Surgery
Trauma, Hemostasis, Coagulopathy, Resuscitation
1.55
article

Prehospital plasma transfusion versus standard of care following traumatic injury: a review of the systematic reviews and a meta-analysis

Łukasz Szarpak, Başar Cander, Ayman El‐Menyar, Sandro Rizoli, Naushad Khan, Fernando Antônio Campelo Spencer Netto, Mashhood Naduvilekandy, Mohammad Asim, Sagar Galwankar, Ammar Al‐Hassani, Rubén Peralta, Hassan Al-Thani
article en
1 citations

Abstract

The overall pooled analysis revealed no significant benefit to PHP transfusion in trauma patients; however, sensitivity analyses showed a significant association of PHP and lower 24-hour mortality. PHP did not significantly decrease vasopressor use or late mortality; however, it may reduce the total use of RBCs in the first 24 h. Regarding safety, the review findings should be interpreted cautiously. Umbrella review was not conducted due to the heterogeneity and inconsistent inclusion criteria and outcomes. Further studies are needed to address the inconsistency in the existing evidence and determine whether PHP transfusion should be recommended for trauma patients with clearer and standardized endpoints and adverse event reporting.

European Journal of Trauma and Emergency SurgeryVol. 51(1)
John Paul II Catholic University of Lublin (PL), Bezmiâlem Vakıf Üniversitesi (TR), Universidad Nacional Pedro Henríquez Ureña (DO), Sarasota Memorial Hospital (US), Weill Cornell Medical College in Qatar (QA), Hamad Medical Corporation (QA)
Openalex Percentile: Top 13%
Trauma, Hemostasis, Coagulopathy, Resuscitation
1.55
DOIOpen Access PDFOpenAlex
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