L.Fermentum CECT5716 and B.Breve CECT7263 on premature infants morbidities: a randomized clinical trial
The study responds to scientific societies' request for more clinical trials to strengthen the currently low level of evidence on probiotics' safety and benefits for preterm infants. The study presents evidence supporting the safety and the effect of two different doses of a combination of two human milk-derived probiotic strains in preterm infants. The study indicates that a low dose of probiotics may be sufficient to achieve beneficial effects in preterm infants. These findings will inform future research on optimizing probiotic dosing in this population.
Authors
- Jose A. Maldonado-Lobón
- Almudena Alonso‐Ojembarrena (ORCID: https://orcid.org/0000-0002-2413-9758)
- Ruth Blanco-Rojo (ORCID: https://orcid.org/0000-0002-6159-3597)
- J. A. Rubio
- José María Lloreda García (ORCID: https://orcid.org/0000-0002-1474-5586)
- Mónica Olivares (ORCID: https://orcid.org/0000-0002-8596-9923)
- María Teresa de Benito Guerra
- E Martín Álvarez
- Manuela Peña‐Caballero (ORCID: https://orcid.org/0000-0002-5321-3785)
- Carmen Macías Díaz
- María Eugenia Sáez (ORCID: https://orcid.org/0000-0001-9299-2534)
- Tomás Sánchez‐Tamayo (ORCID: https://orcid.org/0000-0002-8752-3060)
- Luz Martínez Pardo
- José Suazo (ORCID: https://orcid.org/0000-0002-4175-5536)
- L Serrano López
- Juan Antonio Ruiz Moreno
- Mercedes Granero Asencio
- David Mora Navarro
- Eva Torres Begara
Institutions
- Universidad de Granada (ES)
- Universidad de Jaén (ES)
- Hospital Costa del Sol (ES)
- Hospital Universitario Virgen Macarena (ES)
- Hospital Regional Universitario de Málaga (ES)
- Hospital Universitario Virgen de las Nieves (ES)
- Complejo Hospitalario de Jaén (ES)
- Biomedical Research and Innovation Institute of Cadiz (ES)
- Hospital Juan Ramón Jiménez (ES)
- Hospital Universitario de La Princesa (ES)
- Hospital Universitario Puerta del Mar (ES)
- Santa Lucía University General Hospital (ES)
- Hospital Universitario de Valme (ES)
- Kerry Group (Ireland) (IE)
- Hospital Universitario Virgen del Rocío (ES)
- Hospital Jerez Puerta del Sur (ES)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1038/s41390-025-04633-6
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00