Effects of banana blossom supplementation on metabolic parameters in prediabetic adults: a double-blind randomized clinical trial

Preliminary animal and in vitro studies suggest banana blossoms, a byproduct of banana farming, may help regulate blood sugar and lipid levels and offer antioxidant benefits, though human evidence is limited. This study examined the effects of freeze-dried banana blossom powder (FBP) on fasting blood sugar (FBS), HbA1c, and related health markers in prediabetic Thai adults. In an eight-week double-blind, randomized clinical trial, 42 participants received either 3000 mg/day of FBP or a placebo. Block randomization and third-party blinding ensured unbiased procedures, with similar baseline characteristics across groups. At week eight, measurements included FBS, HbA1c, lipid profile, insulin, liver and kidney function, blood pressure, and anthropometric data. FBP had no significant impact on FBS, HbA1c, lipid profile, or insulin. However, participants in the FBP group showed significant reductions in body weight, BMI, and diastolic blood pressure. Improved bowel movements were also reported, suggesting benefits from FBP’s bioactive compounds. No significant changes in glycemic parameters were detected following FBP supplementation. FBP was well tolerated with no adverse effects, supporting its potential as a functional food for managing weight and blood pressure. The trial was registered at TCTR20240326003.