Immune modulation mimics damage control orthopaedics’ upregulation of anti-inflammatory miRNA-21/23a/27a and miRNA-30b in the lung after polytrauma in pigs
This study indicates that combined inhibition of C5 and CD14 effectively reduces posttraumatic histopathological changes in lung tissue associated with less inflammatory and fibrotic miRNA expression, compared to both the DCO and ETC groups.
Authors
- Frank Hildebrand (ORCID: https://orcid.org/0000-0001-7729-9838)
- Markus Huber‐Lang (ORCID: https://orcid.org/0000-0003-2359-6516)
- Rald V. M. Groven (ORCID: https://orcid.org/0000-0001-8733-289X)
- Tom Eirik Mollnes (ORCID: https://orcid.org/0000-0002-5785-802X)
- Martijn van Griensven (ORCID: https://orcid.org/0000-0001-5104-9881)
- Klemens Horst (ORCID: https://orcid.org/0000-0002-7162-6153)
- Carlos Julio Peniche Silva (ORCID: https://orcid.org/0000-0002-2290-8269)
- Johannes Greven (ORCID: https://orcid.org/0000-0003-2856-4804)
- Elizabeth R. Balmayor (ORCID: https://orcid.org/0000-0002-0484-4847)
- Ümit Mert (ORCID: https://orcid.org/0000-0001-6125-6040)
- Belinda Freiin von Münchhausen (ORCID: https://orcid.org/0009-0009-1412-0218)
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
- Nordland Hospital (NO)
- Universitätsklinikum Aachen (DE)
- Inspire Institute (US)
- University Hospital Ulm (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- European Journal of Trauma and Emergency Surgery
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1007/s00068-025-03005-3
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Erasmus+