Gold-Catalyzed Cascade Cyclization and Amidation of 2-Alkynyl Arylazides To Access 3-Amidoindoles
A gold-catalyzed cyclization and amidation of 2-alkynyl arylazides with nitriles and water is described. This protocol affords structurally diverse 3-amidoindoles in moderate to excellent yields under mild reaction conditions via the key benzene-fused α-imino gold carbene intermediate. Mechanistic studies reveal that the oxygen atom in the amide group is derived from water.
Authors
- Anyuan Cao (ORCID: https://orcid.org/0000-0001-8014-9187)
- Chengfeng Zhu (ORCID: https://orcid.org/0000-0002-9676-6750)
- Mengcheng Wang (ORCID: https://orcid.org/0000-0002-4074-4210)
- Xiang Wu (ORCID: https://orcid.org/0000-0001-5428-9063)
- Zhen-Yu Wang (ORCID: https://orcid.org/0000-0002-5872-017X)
- Si-Ru Wang
- Jianping Wu (ORCID: https://orcid.org/0000-0002-9924-7307)
- Yanming Fu (ORCID: https://orcid.org/0000-0001-8296-3166)
Institutions
- Hefei University of Technology (CN)
- Veterinary and Agrochemical Research Centre (BE)
- Ministry of Industry and Information Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1021/acs.orglett.5c04581
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00