Trends in Alzheimer’s Disease Mortality in the Mississippi Delta, 2016–2022

Background/Introduction: Alzheimer’s disease (AD) is a progressive neurological disorder and one of the leading causes of death among older adults in the United States. It causes gradual cognitive decline, memory loss, and impaired functioning. Vulnerable populations—especially those living in rural and predominantly Black communities like the Mississippi Delta—are disproportionately affected. Despite high Alzheimer’s disease mortality rates in Mississippi, limited research has analyzed recent trends disaggregated by race, gender, and geography. This study evaluated trends in AD mortality in the Mississippi Delta between 2016 and 2022 to inform equitable public health responses. Methods: This trend study used age-adjusted mortality rates (AAMRs) for adults aged 65 and older to examine Alzheimer’s disease deaths. AAMRs allow for fair comparisons across groups by adjusting for differences in population age structures. Mortality data were obtained from the Mississippi Statistically Automated Health Resource System (MSTAHRS), a statewide health surveillance system managed by the Mississippi State Department of Health. Joinpoint regression analysis was used to identify statistically significant changes in mortality trends over time using Annual Percent Change (APC) and Average Annual Percent Change (AAPC), with 95% confidence intervals (CIs). AAPC denotes an average percentage change in mortality trends over a seven-year period. Joinpoint regression is an appropriate method for detecting points at which linear trends change significantly, especially in chronic disease mortality analysis. Results: From 2016 to 2022, Alzheimer’s disease mortality significantly increased among Black individuals (AAPC = 8.3%, 95% CI [2.6 to 16.0]; p < 0.05) and declined among White individuals (AAPC = −2.9%, 95% CI [−12.3 to 7.6] p < 0.05). Gender-specific analyses showed slight, non-significant increases among both males and females. County-level disparities were evident: counties such as Sharkey experienced increases exceeding 10%, while Humphreys counties showed declines. Racial disparities in AD mortality were more pronounced than gender differences. Conclusions: This study reveals widening racial and geographic disparities in Alzheimer’s disease mortality across the Mississippi Delta. The statistically significant increase among Black seniors highlights structural inequities in early diagnosis, access to culturally appropriate care, and chronic disease management. These findings support the need for targeted public health interventions, such as the expansion of rural memory clinics, culturally competent outreach, and Medicaid-supported long-term care. Strengthening surveillance systems like MSTAHRS is critical to tracking disparities and advancing equity in dementia-related mortality.