Ddx3xa mutations drive cardiac defects in a zebrafish model via dysregulation of wnt/β-catenin signaling
This study provides the first evidence that <i>ddx3xa</i> regulates cardiac morphogenesis by modulating the Wnt/β-catenin signaling pathway, offering direct experimental insight into the mechanisms underlying cardiac comorbidities in DDX3X syndrome. It also highlights the unique value of the zebrafish model for dissecting conserved pathogenic pathways and exploring targeted therapeutic strategies.
Authors
- Lin Mei (ORCID: https://orcid.org/0000-0001-5772-1229)
- Xiongwei Fan (ORCID: https://orcid.org/0000-0001-8833-2699)
- Yi Kang (ORCID: https://orcid.org/0000-0002-4282-1013)
- Ping Zhu (ORCID: https://orcid.org/0009-0004-9184-0677)
- Fang Li (ORCID: https://orcid.org/0000-0001-9180-3615)
- Yu Chen (ORCID: https://orcid.org/0000-0001-9367-495X)
- Haochen Wang (ORCID: https://orcid.org/0009-0004-2014-6522)
- Yongqing Li (ORCID: https://orcid.org/0000-0001-8266-924X)
- Yingze Zhang (ORCID: https://orcid.org/0000-0002-2161-7785)
- Xueting Yang
- Xiaoyan Cai (ORCID: https://orcid.org/0000-0002-8351-4837)
- Zhigang Jiang (ORCID: https://orcid.org/0000-0002-2574-0086)
- Xiushan Wu
- Wuzhou Yuan
- Yuequn Wang
- Z. Jiao
Institutions
- Hunan Normal University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fmolb.2025.1689202
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Guangdong Special Support Plan